Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

Tang-Du Hospital20 enrolled

Overview

Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes. Perfusion measurement has been shown to improve sensitivity and predictive value for tumor grading and prognosis, also as a predicator of recovery with reperfusion in patients of acute ischemic stroke.Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy Volunteers

Interventions

different low b-values distributionOTHER

Eligibility

Sex: MALEMin age: 25 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * no hypertension or cerebral vascular diseases, * no systemic metabolic disease; * no infection or fever; * no use of corticosteroid drugs; * no MRI contraindication. Exclusion Criteria:

Outcomes

Primary Outcomes

Parameters D* and f in healthy white matter or gray mater

Time frame: 2-3 days

Data from ClinicalTrials.gov

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