Study of Ofatumomab in Combination With ICE-chemotherapy in Patients With Diffuse Large B-cell Lymphoma (DLBCL)

Inclusion Criteria: 1. Refractory or relapsed CD20 positive DLBCL following rituximab combined with chemotherapy. 2. Participants must have measurable disease 3. ECOG performance status 0-2 4. Unless due to lymphomatous involvement, participants must have adequate organ and marrow function as defined below: * Hemoglobin ≥ 10g/dL * Absolute neutrophil count ≥ 1500/mm3 * Platelets ≥ 100 000/mm3 * ALT and AST ≤ 3 x upper limit of normal (ULN), * Total serum bilirubin ≤ 1.5 x ULN * Serum creatinine ≤ 1.5 x ULN 5. Fully recovered (≤ Grade 1 or returned to baseline or deemed irreversible) from the acute effects of prior cancer therapy before initiation of study drug 6. Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: 1. Any previous cancer therapy for lymphoma, with the exception of Rituximab in combination with chemotherapy (not more than 1 prior line of chemotherapy) 2. Participants who have had systemic anti-cancer therapy within 3 weeks (8 weeks for nitrosoureas or mitomycin C) prior to study entry 3. Participants who have had radiotherapy and/ or major surgery within 3 weeks prior to study entry 4. Participants who have had systemic corticosteroids for the purpose of treating lymphoma within 2 weeks prior to study entry are ineligible. Patients receiving stable (not increased within the last month) chronic doses of systemic corticosteroids with a maximum dose of 20 mg of prednisolone (or equivalent) per day are eligible if they are being given for disorders other than lymphoma 5. Concurrent use of any other anti-cancer therapies or study agents. 6. Presence of symptomatic or uncontrolled brain or central nervous system lymphomatous lesions 7. Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, clinically significant cardiac disease including a history of cardiac disease or congestive heart failure \> NYHA class 2, unstable angina (anginal symptoms at rest) or new-onset angina within the last 3 months or myocardial infarction within the past 6 months, significant cardiac arrhythmias and/ or requiring anti-arrhythmics; pulmonary disease; liver diseases such as cirrhosis, chronic active or persistent hepatitis; or acute/ chronic medical/ psychiatric illness/ social situations or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or limit compliance with study requirements, or interfere with the interpretation of study results, and in the judgment of the investigator would make the patient inappropriate for entry into this study. 8. Known or suspected hypersensitivity to study treatments. 9. History of HIV or Hepatitis C 10. Individuals with a history of a different malignancy, other than treated cervical cancer in situ, basal cell or squamous cell carcinoma of the skin, are ineligible, except if they have been disease-free for at least 5 years, and are deemed by the investigator to be at low risk for recurrence of that malignancy OR other primary malignancy is neither currently clinically significant nor requiring active intervention. 11. Pregnant or lactating women. 12. Women of childbearing potential, including women whose last menstrual period was less than one year prior to screening, unable or unwilling to use adequate contraception from study start to one year after the last dose of ofatumumab therapy. Adequate contraception is defined as hormonal birth control, intrauterine device, double barrier method or total abstinence. Women of childbearing potential must have a negative pregnancy test prior at screening. 13. Male subjects unable or unwilling to use adequate contraception methods from the time of first dose of study medication until one year after the last dose of ofatumumab.