Epigenetic Reprogramming in Relapse AML

Inclusion Criteria: The eligibility criteria listed below are interpreted literally and cannot be waived. • Age: Patients must be ≥ 1 and ≤ 25 years of age when originally diagnosed with AML. * Diagnosis: o Patients must have a diagnosis of AML with \> 5% blast in the bone marrow and fall into one of the categories listed below: * Any patient in 1st or greater relapse OR Patients failed to go into remission after first or greater relapse OR Patients failed to go into remission from original diagnosis after two or more induction attempts. o Patients with CNS 1 or CNS 2 leukemia are eligible * Performance Level: (See Appendix 2 for Performance Scales) o Karnofsky Performance Status ≥ 50% for patients 16 years and older o Lansky Play Score ≥ 50 for patients under 16 years of age * Life Expectancy: o Patients must have a life expectancy ≥ 8 weeks as determined by the enrolling investigator. * Prior Therapy: o Cytotoxic Therapy: At least 7 days must have elapsed from prior chemotherapy with the exception of hydroxyurea which can be used up to 24 hours of starting this protocol therapy. o Hematopoietic Stem Cell Transplant (HSCT): Patients who have experienced their relapse after a HSCT are eligible, provided they have no evidence of active Graft-versus-Host Disease (GVHD). o Prior Demethylating and/or HDAC Inhibitor Therapy: Patients who have received prior DNMTi (e.g. decitabine) and/or HDACi (e.g. vorinostat) are eligible to participate in this Phase 1 study. o Biologic (anti-neoplastic agent): At least 7 days after the last dose of a biologic agent. For agents that have known adverse events occurring beyond 7 days after administration, this period must be extended beyond the time during which adverse events are known to occur. The duration of this interval must be discussed with the study chair o Monoclonal Antibodies: At least 3 half-lives of the antibody must have elapsed after the last dose of monoclonal antibody. (i.e. Gemtuzumab = 36 days) * Immunotherapy: At least 42 days after the completion of any type of immunotherapy, e.g. tumor vaccines. * XRT: \> 14 days for local palliative XRT for CNS chloromas; No washout period is necessary for other chloromas; \> 30 days must have elapsed if prior TBI, craniospinal XRT. * Organ Function: * Patients must have acceptable organ function as defined within 7 days of study registration * Renal: creatinine clearance ≥ 60 mL/min/1.73 m2 or serum creatinine based on age and gender as follows: Maximum Serum Creatinine (mg/dL) Age Male Female 1 month to \< 6 months 0.4 0.4 6 months to \< 1 year 0.5 0.5 1. year to \< 2 years 0.6 0.6 2. years to \< 6 years 0.8 0.8 6 years to \< 10 years 1.0 1.0 10 years to \< 13 years 1.2 1.2 13 years to \< 16 years 1.5 1.4 * 16 years 1.7 1.4 * Hepatic: ALT \< 5 × upper limit of normal (ULN) and total bilirubin ≤ 1.5 × upper limit of normal (ULN) for age. The hepatic requirements are waived for patients with known or suspected leukemia liver involvement who would otherwise be eligible after consultation with the Study Chair or Vice Chair. * Cardiac: left ventricular shortening fraction \> 27% by ECHO/MUGA or an ejection fraction ≥ 40% by ECHO/MUGA * Reproductive Function: * Female patients of childbearing potential must have a negative urine or serum pregnancy test confirmed prior to enrollment. * Female patients with infants must agree not to breastfeed their infants while on this study. * Male and female patients of child-bearing potential must agree to use an effective method of contraception approved by the investigator during the study. • Sexually active females of child bearing potential must agree to use adequate contraception (diaphragm, birth control pills, injections, intrauterine device \[IUD\], surgical sterilization, subcutaneous implants, or abstinence, etc.) for the duration of treatment and for 2 months after the last dose of chemotherapy. Sexually active men must agree to use barrier contraceptive for the duration of treatment and for 2 months after the last dose of chemotherapy. * Voluntary written consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care. Exclusion Criteria: Patients will be excluded if they meet any of the following criteria * They are unable to swallow Vorinostat capsules or take oral solution. * They are currently receiving other investigational drugs. * There is a plan to administer non-protocol chemotherapy, radiation therapy, or immunotherapy during the study period. * They have significant concurrent disease, illness, psychiatric disorder or social issue that would compromise patient safety or compliance, interfere with consent, study participation, follow up, or interpretation of study results. * They have a known allergy to any of the drugs used in the study. * Patients with Down syndrome are excluded. * They are receiving Valproic Acid (VPA) therapy. * Patients with Acute Promyelocytic Leukemia (APL, APML) are excluded * Patients with documented active and uncontrolled infection at the time of study entry are not eligible.