A Study of the Abuse Liability Potential of ALKS 5461 in Healthy, Non-Dependent, Recreational Opioid Users

Inclusion Criteria: * Have a body mass index (BMI) within the range of 18.0 to 30.0 kg/m2, inclusive, and a minimum weight of at least 50.0 kg * Be a current recreational opioid user who has used opioids for non-therapeutic purposes (ie for psychoactive effects) at least 10 times in their lifetime * Agree to use an approved method of contraception for the duration of the study unless surgically sterile or postmenopausal * Be willing and able to abide by all study requirements and restrictions * Additional criteria may apply Exclusion Criteria: * Have evidence of drug or alcohol dependence within the past 2 years * Have a positive drug screen for opioids, amphetamines, cocaine, or benzodiazepines upon admission to the clinic * Have a history of severe allergic reaction (including anaphylaxis) to any food, medication, or bee sting * Be currently pregnant, breastfeeding, or planning to become pregnant during the study * Currently have or have a history of allergy or hypersensitivity to opioid agonists, opioid antagonists or related drugs (eg, oxycodone, morphine, naltrexone, and naloxone) * Have a positive test result for hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) * Have donated or lost more than 500 mL whole blood * Additional criteria may apply.