Delirium is a common and serious condition and is associated with adverse outcome. The elderly who have cognitive dysfunction are expected to show delirium more frequently. It is most likely that delirium represents a response to impaired cholinergic neurotransmission. Investigators aimed to establish the preventive effect of the cholinesterase inhibitor, rivastigmine patch, on the post-operative delirium limited to femur neck fracture operation in patients at risk of dementia.
Investigators evaluated the delirium prevention effect of rivastigmine patch in patients with femur neck fracture and cognitive impairment. Investigators measured the frequency and severity of post-operation delirium in the patch applied and non-applied subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
62
acetylcholine esterase inhibitor
the number of participants with delirium
investigators evaluated the delirium frequency in rivastigmine applied participants comparing with non-applied participants.
Time frame: up to 7th days
delirium severity using delirium rating scale
to compare the severity of delirium in rivastigmine patch applied participants with non-applied
Time frame: up to 7th days
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