The purpose of this study is to investigate the potential healing properties of phenytoin. The investigators will use the donor site of a split skin thickness graft (SSTG) to model a basic wound in a randomized controlled trial of topical phenytoin against current best clinical practice. The investigators aim to demonstrate a dose dependent effect. The investigators hypothesis, based on previous clinical experience at our center and on current available literature, that phenytoin will reduce wound healing time.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
Topical use of phenytoin solution on dressings of split thickness skin graft sites.
Children's Surgical Centre
Phnom Penh, Cambodia
RECRUITINGPercentage rate of re-epithelialization
Pictures taken of wound site every other day will be analysed using imaging software for size of wound. Percentage rate will be calculated from this.
Time frame: Participants will be followed for the duration of hospital stay, an expected average of 20 days
Appearance of infection
Pictures taken of wound site every other day will be analysed using imaging software and the Southampton wound grading scale
Time frame: Participants will be followed for the duration of hospital stay, an expected average of 20 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.