The Role of Whey and Lupin in Glycemic Control (Nutritional Pre-Study)

DLR German Aerospace Center12 enrolled

Overview

The study compared the acute effects of the supplementation of a standardized meal with either lupin or whey protein or no protein on the whole-body glucose and insuline metabolism.

The nutritional pre-study had the following key objectives: Primary objective: \- Lupin protein lowers the postprandial blood glucose level equivalent to or to a greater extent than whey protein. Secondary objective: \- Lupin protein has an equivalent or a stronger insulinotropic effect than whey protein.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Whole Body Glucose and Insulin Metabolism

Interventions

Lupin ProteinDIETARY_SUPPLEMENT

Subjects received a standardized test meal rich in carbohydrates and supplemented with lupin protein.

Whey ProteinDIETARY_SUPPLEMENT

Subjects received a standardized test meal rich in carbohydrates and supplemented with whey protein.

ReferenceOTHER

Subjects received a standardized test meal rich in carbohydrates and not supplemented with any protein.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female and male volunteers * Age: between 20 and 45 years * Body mass index (BMI): 20-28 kg/m² * Fasting blood glucose within normal ranges (70-99 mg/dl; 29-42 mmol/mol Hb) * Glycated hemoglobin HbA1c within normal ranges (4-6%) * Agreement and signed informed consent before the study Exclusion Criteria: * Diabetes mellitus * Increased bleeding tendency (hemophilia, regular use of anticoagulants) * Allergy to nuts, legume or milk protein * Drug, medication or alcohol abuse (frequent consumption of more than 20-30g alcohol/day) * Intake of medication during the study * Smoker * Competitive athletes * Extreme eating habits (vegan, special diets) * Any other condition classed as unsuitable by the executive medical director

Outcomes

Primary Outcomes

Blood Glucose Metabolism by Blood Glucose and Serum Insulin (composite)

Time frame: up to 180 minutes after the test meal was finished

Data from ClinicalTrials.gov

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