Impact of Aerobic Training and Combined in Inflammatory Markers in Patients With Adolescent Idiopathic Scoliosis

Faculdade de Ciências Médicas da Santa Casa de São Paulo40 enrolled

Overview

Inflammatory markers have been analyzed in several diseases of unknown etiology, in the expectation of increasing therapeutic perspectives. This possibility arises from the different levels of tissue injury with low-grade chronic inflammation that have been observed in studies in which the markers were not evaluated traditionally, and today have influenced clinical management. The investigators aimed, therefore, to evaluate the inflammatory markers in patients with AIS before and after aerobic and combined exercise training.

Inflammatory markers have not been evaluated in adolescent idiopathic scoliosis (AIS), but this deformity potentially involves various musculoskeletal structures permanently, which justifies the analysis. A low-grade chronic inflammation may be related to the lower capacity in exercise performance observed in this population, which must be stimulated to perform standardized physical activity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Scoliosis Adolescent Scoliosis

Interventions

aerobic exerciseOTHER

aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate)

combined exerciseOTHER

aerobic training 40 minutes on a treadmill (60-80% of maximum heart rate); resisted training in equipment and free weights for 10 minutes with a set of 10 repetitions in quadriceps, triceps and biceps of the arms and legs

treadmillDEVICE

Eligibility

Sex: ALLMin age: 10 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * thoracic curvature ≥ 45 degrees * indication for surgical treatment of spinal deformity * absence of pulmonary, cardiac, articular or neurological disorder, atopic dermatitis and previous or current allergy * agree part in the research with a assent statement and the person responsible with the consent form and informed Exclusion Criteria: * acknowledged chronic liver or kidney inflammatory disease * use of corticosteroids, acetylsalicylic acid or other nonhormonal anti-inflammatory clinical or laboratorial evidence of infection * severe obesity

Locations (1)

Santa Casa of Sao Paulo Medical School

São Paulo, Brazil

Outcomes

Primary Outcomes

interleukin 1

Inflammatory Markers

Time frame: change from baseline in interleukin 1 at 3 months

interleukin 6

Inflammatory Markers

Time frame: change from baseline in interleukin 6 at 3 months

interleukin 8

Inflammatory Markers

Time frame: change from baseline in interleukin 8 at 3 months

Secondary Outcomes

distance in six-minute walk test

analysis of distance

Time frame: change from baseline in distance at 3 months

oxygen saturation in six-minute walk test

analysis of oxygen saturation at end of test

Time frame: change from baseline in oxygen saturation at 3 months

systolic blood pressure in six-minute walk test

analysis of systolic blood pressure at end of test

Time frame: change from baseline in systolic blood pressure at 3 months

diastolic blood pressure in six-minute walk test

analysis of diastolic blood pressure at end of test

Time frame: change from baseline in diastolic blood pressure at 3 months

heart rate in six-minute walk test

analysis of heart rate at end of test

Time frame: change from baseline in heart rate at 3 months

respiratory frequency in six-minute walk test

analysis of respiratory frequency at end of test

Time frame: change from baseline in respiratory frequency at 3 months

Borg scale in six-minute walk test

analysis of Borg scale at end of test

Time frame: change from baseline in Borg scale at 3 months

forced vital capacity (FVC)

analyzed in liters or % of predicted of lung capacity variation from baseline at 3 months