A Study to Evaluate the Safety of AERAS-402 in Adults Recently Treated for Pulmonary TB

Inclusion Criteria: 1. Is male or female. 2. Is age 18 through 45 years on Study Day 0. 3. Has completed the written informed consent process. 4. Has a history of pulmonary tuberculosis diagnosed by either a sputum smear positive for acid-fast bacilli (AFB) or a sputum culture positive for Mtb. 5. Has initiated effective chemotherapy for tuberculosis between one month (30 days) and four months (120 days) before Study Day 0, with improvement in clinical signs and/or symptoms of disease, OR: has initiated effective chemotherapy for tuberculosis at least 12 months (360 days) before Study Day 0, and is considered cured. 6. For subjects currently receiving chemotherapy for tuberculosis they must have been fully compliant with previously prescribed tuberculosis therapy and agree to complete currently prescribed tuberculosis therapy. 7. Agrees to avoid elective surgery for the full duration of the study. 8. For female subjects: agrees to avoid pregnancy for the full duration of the study. 9. Agrees to stay in contact with the study site for the full duration of the study, providing updated contact information as necessary, and has no current plans to move from the study area during the duration of the study. 10. Has completed simultaneous enrollment in Aeras Vaccine Development Registry Protocol. Exclusion Criteria: 1. Fever ≥37.5°C. 2. Evidence of a new acute illness that may compromise the safety of the subject in the study. 3. Evidence of any significant active infection other than tuberculosis. 4. Evidence of central nervous system tuberculosis or pleural tuberculosis. 5. Previous medical history that may compromise the safety of the subject in the study, including but not limited to: severe impairment of pulmonary function from tuberculosis infection or other pulmonary disease; chronic illness with signs of cardiac or renal failure; suspected progressive neurological disease; or uncontrolled epilepsy or infantile spasms. 6. Evidence of any systemic disease or any acute or chronic illness that may interfere with the evaluation of the safety of the vaccine. 7. History or laboratory evidence of any past, present or future possible immunodeficiency state, including but not limited to any laboratory indication of HIV-1 infection. 8. History of allergic disease or reactions likely to be exacerbated by any component of the study vaccine. 9. Received any investigational drug therapy or vaccine within 182 days before the first dose of study vaccine in this protocol. 10. Received any adenovirus-based vaccine previously. 11. For female subjects: Currently pregnant, lactating/nursing, or a positive serum or urine βhCG 12. Severe anemia, defined as a hemoglobin less than 10 g/dL or a hematocrit less than 30 percent. 13. Urine toxicology screen positive for opiates, cocaine, or amphetamines. 14. Anal intercourse with another man at least one time (with or without condoms). 15. Exchange of goods, money, services or drugs for sex. 16. Use of intravenous drugs. 17. Sexual intercourse or genital contact within the last 12 months with a known HIV positive individual. 18. Vaginal intercourse within the last 12 months without use of a condom with a known user of intravenous drugs. 19. Oral to genital contact within the last 12 months with a known user of intravenous drugs. 20. Vaginal intercourse within the last 12 months without use of a condom with an individual known to have more than one sex partner. 21. Oral to genital contact within the last 12 months with an individual known to have more than one sex partner.