Transplantation of Autologous Oral Mucosal Epithelial Sheets for Limbal Stem-cell Deficiency

Inclusion Criteria: * Among patients with bilateral limbal stem-cell deficiency, those who meet all the criteria listed below when they give their informed consent to participate in this research will be included. 1. Patients in whom the eye(s) (subject to the interventional therapy) show(s) loss or dysfunction of corneal epithelial stem cells throughout the total\* circumference of the cornea 2. Patients in whom the corneal surface of the eye(s) (subject to the investigational therapy) is(are) entirely enveloped by conjunctival tissue 3. Patients of both genders aged ≥20 years when they give their informed consent 4. Patients who have given their own written consent to participate in this clinical research (The target disease is bilateral limbal stem-cell deficiency, although it is not always necessary that the both eyes of the patient meet the inclusion criteria.) Exclusion Criteria: 1. Patients who are or may be pregnant, and patients who are breast feeding 2. Patients with infections (HBV, HCV, HIV, HTLV-1) 3. Patients with extreme hypolacrimation resistant to therapy 4. Patients from whom oral mucosal specimens cannot be collected because clear scar formation or inflammatory findings are noted in a cell-collection site of the mucosal membrane 5. Patients whose score of Performance Status (PS\*) is 3 or more 6. Any others who are judged by the chief subinvestigator to be ineligible for this clinical research, due to the presence of complications, etc.