Bioavailability and Metabolism of Avenanthramide: a Novel Oat Phytochemical

Inclusion Criteria: * Male and female non-obese subjects (18kg/M2\<BMI\<28kg/M2) * Age 20-45 years) * Sign an informed consent form approved by UMN-IRB * Willing to avoid oat consumption and rigorous physical activity the day prior to and through test, and consume a low-flavonoid diet for 1 week prior to the study Exclusion Criteria: * Presence of GI conditions that interfere with absorption; * Clinically significant endocrine, cardiovascular, pulmonary, renal, hepatic, pancreatic, biliary or neurologic disorders; * Major trauma or surgery within 3 months of visit; * Cancer in the prior 2 years; * Allergic to oat products; * Women who are pregnant or lactating; * Smoking; * Drinking alcohol \>5 drinks/week; * Using nutraceuticals; * Blood pressure medication; * NSAID (\>800 mg ibuprofen/week); * Vitamin supplementation; * Anticoagulants or hypoglycemic drugs; * Oat products consumption the day before the test; * Rigorous physical activity the day before the test; * Consumption of a high-flavonoid diet in the week prior to the test.