Tailored Bowel Preparation According to Bristol Stool Form Scale

Shandong University700 enrolled

Overview

The Bristol stool form scale ( BSFS) based tailored bowel cleansing regimen might be helpful to improve bowel cleansing quality before colonoscopy.

Colonoscopy is the standard approach for evaluating the colon currently. Thorough bowel cleansing is critical for adequate visualization of colonic mucosa during colonoscopy. Inadequate bowel cleansing results in adverse consequences for the examination, including lower adenoma detection rates, longer procedural time, lower cecal intubation rates, shorter intervals between examinations and an estimated 12-22% increase in overall colonoscopy cost.Unfortunately, despite advances in bowel preparation methods, up to one-third of all colonoscopies are reported to have an inadequate bowel preparation. The Bristol stool form scale ( BSFS) was developed in 1988 by O'Donnell LJD et al and was widely applied in both gastrointestinal study and clinical practice. BSFS divides human stool into 7 different styles according to its moisture content. In our clinical work, we find that it is prone to gain poor bowel cleansing quality in patients who pass type 1or 2 stool. Unfortunately, there is lacking of study on tailored bowel preparation according to Bristol stool form scale. Thus, we intend to develop an easy, practical, BSFS based tailored bowel cleansing regimen, in order to serve clinical work and research.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

700

Conditions

Bowel Cleansing Quality

Interventions

Standard Bowel Prep (2L PEG-ELP)DRUG

Subjects whose bristol stool forms are type 1 or 2, will be asked to take standard bowel prep (2L PEG-ELP) the same-day of procedure.

2L PEG-ELP and 10mg bisacodylDRUG

Subjects whose bristol stool forms are type 1 or 2, will be asked to take standard bowel prep (2L PEG-ELP) the same-day of procedure and 10mg bisacodyl the day before procedure.

Standard Bowel Prep (2L PEG-ELP)DRUG

Subjects whose bristol stool forms are type 3 to 7, will be asked to take standard bowel prep (2L PEG-ELP) the same-day of procedure.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients 18 years of age or older, * scheduled to undergo elective outpatient colonoscopy, * and were able to provide informed consent. Exclusion Criteria: * history of colorectal surgery * severe colonic stricture or obstructing tumour * dysphagia * compromised swallowing reflex or mental status * significant gastroparesis or gastric outlet obstruction * known or suspected bowel obstruction or perforation * severe chronic renal failure (creatinine clearance\<30 ml/min * severe congestive heart failure (New York Heart Association class III or IV) * uncontrolled hypertension (systolic blood pressure\>170 mm Hg, diastolic blood pressure\>100 mm Hg) * inflammatory bowel disease or megacolon * dehydration * disturbance of electrolytes * pregnancy or lactation * haemodynamically unstable * unable to give informed consent.

Locations (1)

Department of Gastroenterology, Qilu Hospital, Shandong University

Jinan, Shandong, China

Outcomes

Primary Outcomes

Difference of scores rating by Boston Bowel Preparation Scale among 3 groups.

This is an established rating scale to evaluate the quality of bowel prep. The ratings will be compared among the 3 groups.

Time frame: 9 months

Secondary Outcomes

Rate of non-compliance with instructions among 3 groups.

Time frame: 9 months

Willingness to repeat bowel preparation among 3 groups.

Time frame: 9 months

Polyp detection rate among 3 groups.

Time frame: 9 months

Caecal intubation rate among 3 groups.

Time frame: 9 months

Withdrawal time among 3 groups.

Time frame: 9 months

Data from ClinicalTrials.gov

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