Predicting Relapse After Cocaine Inpatient Cessation

Assistance Publique - Hôpitaux de Paris87 enrolled

Overview

Can brain MRI at entry of cocaine inpatient cessation attempt predict relapse during a three month follow-up ? Hypothesis : White matter losses in the prefrontal cortex are associated with relapse to cocaine use.

A multivariate model using MRI parameters, craving score, impulsivity score, and neuropsychological testing results will be tested to predict relapse or continuous abstinence three month after cocaine inpatient cessation attempt.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cocaine Dependence Cocaine Use Disorder

Interventions

Brain MRI imageryPROCEDURE

Brain MRI performed during the first week of inpatient cocaine cessation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * cocaine dependent patient requiring inpatient cessation * 18 years old and older * giving his/her consent to come back for visits up to three months * having a social insurance Exclusion Criteria: * minor * under guardianship * restraint hospitalization * contraindication to brain MRI * pregnant women

Locations (1)

Service de Psychiatrie, Hôpital Fernand Widal

Paris, France

Outcomes

Primary Outcomes

mean difference of fractional anisotropy of the prefrontal cortex (PFC) in patients abstinent from cocaine 3 months after inpatient detoxification compared to relapsers

Time frame: at 3 months

Secondary Outcomes

Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse

Differences in grey and white matter volumes : voxel-based morphometry (VBM) and in resting-state whole-brain activity default mode network (DMN)

Time frame: at baseline

Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse

Differences in scores of craving (visual scale and Obsessive compusilve craving scale (OCCS) questionnaire) and impulsivity (UPPS)

Time frame: at baseline

Comparisons between patients who remain abstinent from cocaine 3 months after inpatient detoxification and those who relapse

Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task

Time frame: at baseline

Among abstinent patients who remain abstinent at three months only :Differences between baseline and 3 months measures of Diffusion Tensor Imagery (DTI), VBM and DMN

Time frame: at 3 months

Among abstinent patients who remain abstinent at three months only: Differences in scores of craving (visual scale and OCCS questionnaire) and impulsivity (UPPS)

Time frame: at 3 months

Among abstinent patients who remain abstinent at three months only: Differences in performance at the stroop test and in mental flexibility during an implicit set shifting task compared to baseline results

Data from ClinicalTrials.gov

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