Attention Training for Learning Enhancement and Resilience Trial

Posit Science Corporation83 enrolled

Overview

Healthy aging is associated with a decline in multiple cognitive domains, as well as motor control function. The long-term consequences of cognitive and functional impairment resulting from age-related cognitive decline are well documented in the scientific and clinical literature, with significant evidence of related problems with independent functional abilities. This study aims to understand how the experimental computer program can affect cognition and attention in participants with age-related cognitive decline.

Following consent, participants will engage in an assessment process to determine eligibility. Once eligibility is confirmed, participants will be scheduled for another assessment session to determine current level of cognitive function. This process consists of paper-pencil surveys and computerized tests. Following the assessment process, participants will engage in an Internet browser-delivered training sessions conducted on any internet-accessible computer. The computerized training sessions can be done up to 7 times a week (once a day) or at the participant's convenience (the recommended time commitment is 5 times a week). Following the completion of training, the participant's cognitive function will be re-assessed. Participation is voluntary and participants may withdraw from the study at any time.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Age-related Cognitive Decline

Interventions

Computerized Plasticity-Based Adaptive Cognitive TrainingOTHER

Commercially available computerized trainingOTHER

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Participants must be 65 years of age or older * Participants must have a diagnosis of age-related cognitive decline as confirmed by interview and performance on screening assessments * Participants must be fluent English speakers * Participants must have adequate visual, auditory, and motor capacity to use computerized intervention Exclusion Criteria: * Participants with diagnosis of PTSD, depression or other psychologically diagnosable emotional disorder * Participants with a history of conditions that could affect thinking abilities, including brain injury, mental illness, cancer, or other neurological conditions (multiple sclerosis, seizure disorder), HIV/AIDS will be excluded * Participants enrolled in another concurrent research study will be excluded * Participants who have difficulty performing assessments or comprehending or following spoken instructions, in the judgment of the screening clinician, will be excluded * Participants with a current or significant past history of substance abuse will be excluded * Participants who show signs of suicidal ideations or behaviors will be excluded and referred for appropriate treatment

Locations (2)

University of Iowa

Iowa City, Iowa, United States

Harvard Medical School

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Attention Measures aimed to test attention

Measures aimed to test attention

Time frame: 6 months

Executive Function

Tasks targeting inhibitory control

Time frame: 6 months

Functional Capacity

Performance on directly observable functional measure

Time frame: 6 month

Secondary Outcomes

Quality of Sleep

assessing sleep quality

Time frame: 6 months

Data from ClinicalTrials.gov

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