AZD9150, a STAT3 Antisense Oligonucleotide, in People With Malignant Ascites

-INCLUSION CRITERIA: 1. Patients must have histologically or cytologically confirmed gastrointestinal (G)I malignancies or ovarian cancer prior to entering this study. 2. Histologically confirmed metastatic ovarian or GI malignancy with malignant ascites amenable for paracentesis. Adjudication of malignant ascites can be made on clinical grounds e.g. in the absence of cirrhosis or other non-malignant causes of ascites. 3. Patients who have relapsed or are refractory to at least one prior chemotherapy regimen, and for whom no standard therapy exists. There is no limit to the number of prior chemotherapy regimens received. 4. Patients should be off radiation therapy, chemotherapy, investigational agents, hormonal therapy, or immunotherapy for 4 weeks (or 5 half-lives of the therapy, whichever is longer) prior to first dose in the study, and off Bevacizumab 6 weeks. 5. Age greater than or equal to 18 years. 6. Eastern Cooperative Oncology Group (ECOG) performance status \<2 (Karnofsky \>70%) 7. Patients must have normal organ and marrow function as defined below: * leukocytes \>3,000/mcL * absolute neutrophil count \>1,500/mcL without growth-factor support during the past month * platelets \>100,000/mcL at all times during the screening period without platelet transfusion within 3 weeks -total bilirubin \<2 X institutional upper limit of normal * Hemoglobin (Hb) greater than or equal to 9 g/dL without transfusion for 3 weeks * International normalized ratio (INR) \< 2.0 * Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase (SGOT)/alanine aminotransferase (ALT)(serum glutamic pyruvic transaminase (SGPT) \<3 X institutional upper limit of normal, or \<5 ULN for patients with liver metastasis * Creatinine within normal institutional limits OR 8. Patients must have recovered from any acute toxicity related to prior therapy, including surgery. Toxicity should be \< grade 1 9. Ejection fraction \> 50% on echocardiogram. 10. The effects of AZD9150 on the developing human fetus are unknown. For this reason women of child-bearing potential should use reliable methods of contraception from the time of screening until 6 months after discontinuing study treatment. Acceptable methods of contraception include tubal ligation, tricycle combined oral or transdermal contraceptives, copper-banded intra-uterine devices and vasectomized partner. It is not known whether AZD9150 has the capacity to induce hepatic enzymes so hormonal contraceptives should be combined with a barrier method of contraception. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. Women of child-bearing potential must have a negative pregnancy test prior to entry. Male patients should use reliable methods of contraception such as barrier contraception i.e. condoms during sexual activities with women of child-bearing potential and refrain from sperm donation during the trial and for a washout period of at least 6 months. If male patients wish to father children they should be advised to arrange for freezing of sperm samples prior to the start of study treatment. 11. Ability of subject to understand and the willingness to sign a written informed consent document. EXCLUSION CRITERIA: 1. Patients who are receiving any other investigational agents. 2. History of prior Janus kinase (JAK) or signal transducer and activator transcription 3 (STAT)3 inhibitor treatment. 3. Patients with known brain metastases or spinal cord compression should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. 4. Patients must not have other invasive malignancies within the past 3 years (with the exception of adequately treated basal or squamous cell skin cancers, carcinoma in situ of the cervix and ductal carcinoma in situ (DCIS) of breast). 5. History of allergic reactions attributed to compounds of similar chemical or biologic composition to AZD9150. 6. Incompletely healed surgical incision prior to enrolment 7. Ongoing therapy with oral or parenteral anticoagulants (e.g., heparin, warfarin). Lowdose anticoagulants for maintenance of catheter patency are not exclusionary. 8. Any of the following cardiac criteria: * Mean resting corrected Q wave and T wave (QT) interval (QTcF) \> 480 msec obtained from 3 electrocardiograms (ECGs) * Any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g., complete left bundle branch block, third degree heart block 9. Patients with uncontrolled hypertension (systolic blood pressure (SBP)\> 155, diastolic blood pressure (DBP)\> 90), unstable coronary disease (unstable angina, evidence of congestive heart failure (CHF), or myocardial infarction (MI) within 6 months of study) 10. New York Heart Association (NYHA) greater than or equal to Grade II or greater. 11. History of myocardial infarction within 6months prior to screening. 12. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. 13. Pregnant and/or breastfeeding 14. Human immunodeficiency virus (HIV)-positive patients or with history of hepatitis or with current chronic or active hepatitis. A past history of Hepatitis A is allowed. 15. History of recurrent bacterial infections unrelated to hepatocellular carcinoma (HCC) (particularly skin or lung) 16. Bacterial peritonitis within 30 days 17. History of, or presently active or chronic viral infections (i.e. zoster or hepatitis) 18. History of known latent or active tuberculosis, signs of active or latent tuberculosis on chest X-ray, skin test showing an induration of \>10 mm or more or according to local recommendations. 19. Active bleeding disorders and high likelihood of bleeding or conditions or medications known to increase the risk of bleeding. Patients with bleeding diathesis and subjects who are receiving anticoagulation treatment with INR \> 2 are excluded. 20. History of recurrent thrombosis or any thrombosis within the past 6 months 21. Family history consistent with thrombophilia or hypofibrinolysis 22. Patients who have received liver transplantation 23. History of clinically significant liver abnormalities other than liver metastasis 24. Presence of hepatic encephalopathy within 4 weeks of 1st dose 25. Judgment by the investigator that the patient should not participate in the study if the patient is unlikely to comply with study procedures, restrictions and requirements