Cutaneous Microcirculation After Remote Ischemic Preconditioning

Inclusion Criteria: Group A (n=20): Consent-capable male and female patients ≥18 years of age who have sustained a second-degree burn on ≥1% and ≤30% of the surface of the body. Group B (n=20): Consent-capable male and female patients ≥18 years of age who require a skin excision for the purpose of a skin graft. The minimal size of the skin-graft donor site must not be less than 1% of TBSA. Group C (n=20): Consent-capable male and female patients ≥18 years of age suffering from a wound that has not yet healed ≥3 weeks. The minimal size of the wound site must not be less than 1% of TBSA. Group D (n=20): Consent-capable healthy male and female probands ≥18 years of age serving as sham group. None of the the criteria of groups A-C must be evident. No soft tissue injury must be evident. Exclusion Criteria: General exclusion criteria * below 18 years of age * wounds requiring artificial respiration, since consent for the study participation is unobtainable Exclusion Criteria Groups A, B, D: * peripheral arterial occlusive disease * vasculitis * diabetes mellitus * chronic kidney or liver disease * cardiac dysfunction * arterial hypo- or hypertension Anamnestic exclusion criteria * ongoing immunosuppressive or chemotherapy treatment * drug abuse * systemic skin diseases * systemic and local cortisone therapy