The purpose of this feasibility study is to preliminarily evaluate the effects of Tai Chi - a mind-body exercise - on motor and cognitive function as well as quality of life in individuals recently diagnosed with Parkinson's disease (PD).
Specific Aim 1: To assess the feasibility of recruiting and retaining individuals with PD into a 6-month randomized controlled trial of Tai Chi exercise. Specific Aim 2: To collect preliminary data on the efficacy of Tai Chi on improving gait and balance dynamics, physical and cognitive function, exercise activity, self-efficacy, mood, and quality of life in individuals with PD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
32
6-month Tai Chi exercise program meeting 2 times per week plus DVD for home practice
Brigham and Women's Hospital
Boston, Massachusetts, United States
Rate of participant recruitment
Time frame: 24 months
Protocol adherence
The percentage of Tai Chi classes attended and home practice completed by each participant randomized to the experimental arm.
Time frame: 6 months
Retention
The percentage of study visits completed by each participant.
Time frame: 6 months
Change from Baseline in Unified Parkinson's Disease Rating Scale (UPDRS)
Motor symptom severity
Time frame: Baseline and 6 months
Change from Baseline in PDQ-39
PD-related quality of life
Time frame: Baseline and 6 months
Change from Baseline in Physical Activity Status Scale (PASS)
Time frame: Baseline and 6 months
Change from Baseline in Self-Efficacy for Exercise Scale
Time frame: Baseline and 6 months
Change from Baseline in Activity-specific Balance Confidence Scale
Time frame: Baseline and 6 months
Change from Baseline in Profile of Mood State
Time frame: Baseline and 6 months
Change from Baseline in Single leg stance time
Time frame: Baseline and 6 months
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Change from Baseline in Timed Up and Go Test
Time frame: Baseline and 6 months
Change from Baseline in Steady state gait dynamics
Steady state gait dynamics during 90 seconds of continuous over ground walking at preferred speed with and without use of dual task challenges
Time frame: Baseline and 6 months
Change from Baseline in Balance/Postural control
Sway based measures of balance during quiet and tandem standing, with and without dual tasks
Time frame: Baseline and 6 months
Change from Baseline in Cognitive function
Trail Making Test (TMT), The Digit Span Test, Controlled Oral Word Association Test (COWAT), Stroop Color-Word Test
Time frame: Baseline and 6 months