Post operative cognitive dysfunction (POCD) is recognized as a frequent complication after both cardiac and non cardiac surgery, affecting approximately 1/3 of the patients. The aim of this study is to examine the possible effect of the novel reversal agent sugammadex versus neostigmine/ atropine combination on cognitive function of adult patients after elective surgery during the early post operative period as well as at discharge.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SCREENING
Masking
DOUBLE
Enrollment
160
2nd Department of Anesthesiology, Attikon Hospital, 1 Rimini str.
Athens, Greece
Change in the Mini-Mental State Evaluation test
Time frame: Preoperatively, 1 hour postoperatively, at discharge (1-15 days postoperatively)
Change in the clock-drawing test
Time frame: Preoperatively, 1 hour postoperatively, at discharge (1-15 days postoperatively)
Change in the Isaacs set test
Time frame: Preoperatively, 1 hour postoperatively, at discharge (1-15 days postoperatively)
Time from reversal agent administration to extubation
Time frame: After reversal agent administration
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