Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia

N/ACompletedNCT02419547

Brigham and Women's Hospital11 enrolled

Overview

This research study is being done to see whether general anesthesia (GA) affects our ability to start ventricular tachycardia (VT) during an VT ablation procedure. Data collected during this research study will help electrophysiologists and anesthesiologists to make the best decisions about the best anesthetic conditions to use to perform VT ablations. This research study is a "pilot" study. Pilot studies are done on a small group of subjects to learn if a larger study would be useful.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Ventricular Tachycardia

Interventions

VersedDRUG

Phase 1: Standard induction of controled sedation with intravenous agent then programed stimulation to induce ventricular tachycardia

FentanylDRUG

Phase 1: Standard induction of controled sedation with intravenous agent then programed stimulation to induce ventricular tachycardia

PropofolDRUG

Phase 2: Standard induction of GETA with intravenous agent then programed stimulation to induce ventricular tachycardia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with VT and have an implanted ICD who are scheduled for VT catheter ablation. * Patients 18 years of age or older Exclusion Criteria: * Patients with difficult airway management or patients with contra/ relative contra indication for general anesthesia or known allergies to any of the proposed anesthetic agents * Women who are pregnant

Locations (1)

Brigahm and Women's Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Number of Participants Who Had Inducible Ventricular Tachycardia Under General Anesthesia.

Patients before induction of GA undergo noninvasive programmed stimulation (NIPS) using the patient's ICD. Subjects receive minimal versed/fentanyl during the NIPS. The anesthesiologist will decide whether to use propofol prior to the second induction, depending on the patient's cardiac function and hemodynamic status. After induction of GA with IV propofol, programmed stimulation will be performed from the RV catheter. Mapping under volatile agent will commence any time after twice the redistribution half-life of either agent has elapsed (propofol 4-16 mins) or have passed. Once the drug is out of the central compartment it is unlikely to affect myocardial electrolytes or ion channels. GA will be maintained with an inhalation agent, sevoflurane. A repeat programmed stimulation test will be performed. Endpoint for programmed stimulation will be induction of sustained monomorphic VT (SMVT).

Time frame: While under General Anesthesia, an average of 6 hours

Data from ClinicalTrials.gov

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