This study aimed to investigate the effect of enteral feeding's macronutrient composition on inflammatory mediators, oxidative stress and outcomes in Intensive Care Unit (ICU) patients with acute respiratory failure. In this double-blind randomized control trial, 42 patients of both sexes and diagnosed with acute respiratory failure in ICU that receive enteral feeding, will be randomly assigned to three groups of 14 each. First Intervention group; high-protein low-carbohydrate diet with high olive oil, the second intervention group; high-protein low-carbohydrate diet with high sunflower oil and control; high-protein kitchen formula. Intravenous levels of uric acid, high sensitive C-Reactive Protein (hs-CRP), Interleukin 6 (IL-6) and Total Antioxidant Capacity (TAC) measured at days 0 and 10. As well as, organ failure, duration of ventilation, length of ICU stay and mortality rates will be evaluated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
48
Faculty of Nutrition Sciences and Food Technology
Tehran, Iran
length of ventilation
The number of days from the patient intubation to his/her extubation
Time frame: The number of days at least 3, to which days that patient extubated
Levels of high sensitive C-Reactive Protein (hs-CRP) in patient's vein blood
Time frame: 10 days
Levels of Total Antioxidant Capacity (TAC) in patient's vein blood
Time frame: 10 days
Levels of uric acid in patient's vein blood
Time frame: 10 days
Levels of Interleukin 6 (IL-6) in patient's vein blood
Time frame: 10 days
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