Functional Imaging and Reading Deficit in Children With NF1

University Hospital, Toulouse25 enrolled

Overview

A monocenter pilot study on the acceptability and feasibility of a functional MRI protocol in children with NF1 with or without reading disabilities.

The principal aim of the study is to highlight the activation of brain area involved phonological and visuo-spatial processing in children with NF1 with or without reading disabilities.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Neurofibromatosis Type 1

Interventions

Neuropsychological assessmentsOTHER

IQ (WISC-IV) Reading tests (reading accuracy, reading speed, reading comprehension and strategy): Alouette, Lobrot, Odedys tests. Visuo-spatial skill (JLO, Thurston, CORSI tests) Attention (CPT 2, CBCL) Receptive oral language (EVIP)

morphological and functional MRI (fMRI)RADIATION

The fMRI will consider on the acquisition of a 3D anatomical sequence in T1 high resolution in axial slices of 1mm with an acquisition time of 10 min and a T2 sequence and a "Flair" to allow UBO location.

genetic analysisGENETIC

Blood collection in 3 tubes (2 PAXgen® and 1 EDTA) and analysis to study the NF1 gene deletion.

Eligibility

Sex: ALLMin age: 8 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age included between 8 and 12 years * Child presenting a type 1 neurofibromatosis according to 2 criteria in the following criteria list : * At least 6 café au lait spots * 2 or more neurofibromas or 1 plexiform neurofibroma * axillary or inguinal freckling * 1 optic nerf glioma * 2 or more Lisch nodules * 1 osseous lesion as sphenoid dysplasia or thinning of the long bone cortex with or without pseudarthrosis * 1 A first degree relative (parent, sibling, or offspring) with NF1 by the above criteria * Membership in a national insurance * Consent of the child and the parents Exclusion Criteria: * Mental retardation (QI T \< 70) * Treated or untreated epilepsy * Visual deficit (visual Acuteness \< 4/10 * Presence of a symptomatic optic glioma * Presence of a brain tumor.

Locations (1)

CHU Toulouse

Toulouse, France

Outcomes

Primary Outcomes

Percentage of children performing in full the protocol functional MRI

Study the acceptability and feasibility of a functional MRI protocol in children with NF1 with or without reading disabilities.

Time frame: day 1

Secondary Outcomes

blood flow in milliliters per minute

Comparison of brain activations involved in phonological and visuo-spatial processing in 2 groups in children with NF1. 1 group with reading disability and 1 group without reading disability Search for a link between the presence of a large deletion of the gene and learning disorders.

Time frame: day 1

Data from ClinicalTrials.gov

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