Detection of Autologous DEHP (DiEthylHexyl Phthalate)-Free Blood Transfusion in Anti-doping

Centre Hospitalier Universitaire Vaudois20 enrolled

Overview

The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Transfusion Reaction

Interventions

Autologous blood transfusionBIOLOGICAL

Volunteers make a blood donation and after 36 days of storage this blood is re-infused in the same volunteers.

Eligibility

Sex: MALEMin age: 20 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Have to fill the swiss blood donation formulary Exclusion Criteria: * Anemia * Cardiovascular disease * Neurologic disease * Not performed a blood donation for 5 weeks ago the start of the study. * Immunological disease

Locations (1)

Swiss Laboratory for Doping Analyses

Épalinges, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

Measurement of blood parameters profile, iron metabolism and genomic compounds

Blood profiling such as measurement of concentration of different blood cells and hemoglobin will be measured up to 15 days after blood-reinfusion. Concentration of free-iron, ferritin and hepcidin will be measured in plasma and serum up to 15 days after blood re-infusion. Concentration of circulating microRNAs will be measured in plasma also up to 15 days after blood re-infusion. All measures are compared.

Time frame: 1 month

Data from ClinicalTrials.gov

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