Computed Tomography-guided Brachytherapy Plus Chemotherapy for Locally Recurrent Rectum Cancer

Inclusion Criteria: * Limited locoregional recurrence including solitary recurrence at primary tumor bed, solitary intraabdominal peritoneal recurrence, and single regional lymph node recurrence (no more than 3 lymph nodes) based on diagnosis by CT, and confirmed by percutaneous puncture biopsy * Second-line treatment for advanced colorectal cancer,irinotecan was not previously used. * Age range 18-70 years old * ECOG performance status 0-1 * Life expectancy of more than 3 months * Adequate organ function Exclusion Criteria: Previous serious cardiac disease * History of other malignancies except cured basal cell carcinoma of skin and carcinoma in-situ of uterine cervix * Pregnant or lactating women * Chronic inflammatory bowel disease or intestinal obstruction * Serious uncontrolled diseases and intercurrent infection