Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre100 enrolled

Overview

50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13

* The study will be conducted on 100 individuals * 50 chronic periodontitis and 50 healthy individuals will be recruited from the Out Patient Department of Periodontics in the study. * An informed consent will be obtained from patients who wish to participate in the study. * Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959) * After clinical examination, blood samples will be collected and assessed for MMP 13 Gene Polymorphisms. * Subjects will be selected according to the study criteria and divided into two groups (50 each). 1. Test group 2. Control group

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Generalized Adult Periodontitis

Interventions

blood samples collected from all patientsGENETIC

blood samples collected from brachial pluxes

Eligibility

Sex: ALLMin age: 30 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria:• Test group 1. Patients with chronic periodontitis classified according to American Academy of Periodontology ( AAP) 1999 2. Subjects aged between 30-55 years * Control group Systemically and periodontally healthy individuals of same age group Exclusion Criteria: 1. Present and past Smokers 2. Presence of any systemic diseases. 3. Oral diseases other than Periodontitis 4. With a previous history of periodontal treatment in the past 6 months and subjects under any medications. 5. Family history of any diagnosed genetic disorders.

Outcomes

Primary Outcomes

to evaluate the association of 77A/G AND 11A/12A gene polymorphism of mmp-13 in periodontitis effected and healthy individuals

collect DNA samples from serum and evaluate for gene polymorphism

Time frame: 6 months

Data from ClinicalTrials.gov

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