Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects

Inclusion Criteria: 1. 18 years or older 2. Up to 3 treatable cartilage lesions, ICRS IIIa - IVb on the femoral condyles or the trochlea, 3. Symptomatic total treatable area 1-7 cm2. Asymptomatic lesions will not be included in the calculation 4. KOOS Pain score at baseline is not less than 30 and not more than 65 5. Must be physically and mentally willing and able to comply with post- operative rehabilitation protocol and scheduled clinical and radiographic visits. 6. Informed consent signing Exclusion Criteria: 1. Bony defect depth deeper than 8mm, according to imaging Articular cartilage lesions in the tibia or the patella, ICRS grades IVa and IVb 2. Any previous ligamentous repair or malalignment correction in the index knee within the last 3 months 3. Significant instability of the index knee according to IKDC Knee Examination Form 2000, Grade C (abnormal) or D (severely abnormal) 4. Lack of functional remaining meniscus 5. Meniscal transplantation in the past 6 months 6. Malalignment more than 5 degrees varus OR 5 degrees valgus according to standing X-ray 7. Any known tumor of the index knee 8. Any know history of infection of the index knee 9. Any known history of inflammatory arthropathy or crystal-deposition arthropathy 10. Any known systemic cartilage and/or bone disorder such as but not limited to chondrodysplasia or osteogenesis imperfecta 11. Body mass index \>35 12. Osteoarthritis of the index knee graded as 4 according to the Kellgren- Lawrence scale 13. Chemotherapy treatment in the past 12 months 14. Any previous surgical cartilage treatment in the index knee within the last 6 months 15. History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate 16. Patient who is pregnant or intends to become pregnant during the study 17. History of any significant systemic disease, such as but not limited to, HIV infection, hepatitis infection or HTLV infection; known coagulopathies, that might compromise the subject's welfare 18. Known substance abuse or alcohol abuse 19. Participation in other clinical trials within 30 days prior to the study or concurrent with the study 20. Known insulin dependent diabetes mellitus 21. Unable to undergo MRI or X-ray