Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

Chulalongkorn University30 enrolled

Overview

The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Acute Kidney Injury

Interventions

Continuous renal replacement therapy with regional citrate anticoagulationPROCEDURE

CRRT with anticoagulant : regional citrate anticoagulation Filter : AQUAMAX™ (Edwards Lifesciences)

Continuous renal replacement therapy with no anticoagulation or heparinPROCEDURE

CRRT with any anticoagulant : no anticoagulation or heparin Filter : AQUAMAX™ (Edwards Lifesciences)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Systemic inflammatory response syndrome; SIRS \> or = 2 meets definition * Patients with acute kidney injury in the intensive care ward. * Requiring continuous renal replacement therapy. Exclusion Criteria: * Pregnancy * Cirrhosis * End stage renal disease * HIV infection * Serum creatinine in male \> 2 mg/dl and female \> 1.5 mg/dl * Bleeding

Locations (1)

Sasipha Tachaboon

Bangkok, Pathumwan, Thailand

Outcomes

Primary Outcomes

Functions of inflammatory cells

CD11b expression on PMN and HLA-DR expression on monocyte

Time frame: 24 hours

Regulation of inflammatory reactions and and opsonization in microorganisms

C3a and C5a

Time frame: 24 hours

Activity of acute phase protein during acute inflammation

PAI-1

Time frame: 24 hours

Secondary Outcomes

survival rate

Time frame: 28 days

length of ICU stay

Time frame: 28 days

Data from ClinicalTrials.gov

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