Effectiveness and Safety of Electro-acupuncture for Mild-to-moderate Perimenopausal Depression

Inclusion Criteria: * Conforms to the diagnosis standard of STRAW-10 for perimenopause, conforms to the diagnosis standard of The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) for depression, and conforms to the diagnosis standard of The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) F32.0(mild depression) or F32.1(moderate depression); * Fisrt attack during perimenopausal period; * HAMD-17 score \>7 and \<23; * Age ≥45 to ≤55; * No hormone replacement therapy (HRT) or no antidepressant 3 months before into the group; * Sign the consent consent, volunteered for this study Exclusion Criteria: * Fail to rule out the possibility of suicide in depression factor of The Symptom Checklist (SCL-90); * Application of estrogen, progesterone, selective serotonin reuptake inhibitors (SSRIs), soybean isoflavone, vitamin E or black cohosh in recent 4 weeks; * Allergic to citalopram or escitalopram tablets; * Taken the non selective, irreversible inhibitor of monoamine oxidase (MAOIs) in recent 2 weeks; * Taken linezolid, pimozide, tryptophane,tramadol, triptans or other drugs that may cause drug adverse reactions in recent 2 weeks; * Patient with prolongation of the QT interval or congenital long QT syndrome * Taken herbs or products that contain isatin, pilose antler, hawthorn, fleeceflower root, common St.John's wort herb, hypericin; * Ovarian dropsy or hysteromyoma with more than 4cm diameter, oophorectomy, or hysterectomy; * Mandatory indications of hormonotherapy, such as surgery-induced menopause or osteoporosis; * Patient with history of radiotherapy or chemotherapy, or undergoing radiotherapy or chemotherapy; * Vaginal bleeding of undetermined origin; * Patient with coagulation disorders, or taking anticoagulants such as Warfarin, or heparin; * Patient with skin diseases, such as eczema,or psoriasis; * Serious hepatic insufficiency or serious renal inadequacy; * Uncontrolled hypertension, diabetes, or thyroid disease; * Diabetic neuropathy, or malignant tumor; * Pregnancy intention, in pregnancy or lactation; * Regular use of sedative and anti anxiety drugs; * The long-term smoking and/or drinking; * Having Pacemaker or artificial joint； * Electrolyte is disorder, serious heart disease or other potential life-threatening disease patients; * Compliance may be poor or fear of acupuncture.