Artificial Oocyte Activation Comparing Tow Different Agents

Ibn Sina Hospital450 enrolled

Overview

Comparing the efficacy of tow factors for artificial Oocyte Activation for poor quality Oocytes and Teratozoospermia patients.

The IVF outcome had been varied widely with a good portion of total fertilization failure even after the most advanced procedure for this group of patient Intracytoplasmic Sperm Injection, many factors that had been tested for assisting the failed group of patient to be fertilized artificially like Ca Ionophore, Strontium Chloride and others but we decide to compare the clinically proven factors for the efficacy and safety in a well randomized clinical trial and monitor the embryogenesis and pregnancy within the 2 groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

450

Conditions

Oocyte Fertilization

Interventions

Artificial Oocyte activationOTHER

Ca IonophoreDRUG

Strontium ChlorideDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * previous fertilization failure * poor quality Oocytes * poor sperms Exclusion Criteria: * normal patients

Locations (3)

Al Barka fertility center

Manama, Bahrain

Banon Fertility Center

Asyut, Egypt

Ibnsina IVF center

Sohag, Egypt

Outcomes

Primary Outcomes

Pregnancy rate ( % )

Time frame: 9 months

Secondary Outcomes

Blastocyst rate ( % )

Time frame: 9 months

Data from ClinicalTrials.gov

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