A Study of Positron Emission Tomography (PET) With [89]Zr-Df-IAb2M in Patients With High-risk Prostate Cancer

Inclusion Criteria: 1. Histological diagnosis of prostate adenocarcinoma. 2. Patients considered candidates for radical prostatectomy and pelvic lymph node dissection. These patients may or may not have identified nodal metastasis on conventional imaging but would still be candidates for radical prostatectomy and pelvic lymph node dissection. 3. Patients, who are at high-risk for pelvic lymph node metastasis as defined by a lymph node involvement risk of greater than or equal to 20% using the Briganti nomogram. 4. Age ≥ 18 years. 5. Ability to understand and willingness to sign IRB approved consent form 6. For men of child-producing potential, the use of effective contraceptive methods during the study. Exclusion Criteria: 1. Treatment or plans for treatment with radiation therapy, surgery, chemotherapy, or investigational therapy between the time of conventional imaging, \[89\]Zr-Df-IAB2M PET/CT and the surgical resection or biopsy procedures used for the study evaluation. 2. Unwillingness or inability to comply with procedures required in this protocol. 3. Other cancers that might potentially interfere with the reading and interpretation of \[89\]Zr-Df-IAB2M PET/CT scans. 4. Patients who are currently receiving any other investigational agent. 5. Patients who have had or are currently receiving androgen deprivation therapy