The study will evaluate the post-operative morphine-sparing effect, pain reduction, and side effects of a continuous ketamine infusion after tonsillectomy in pediatric patients.
Eligible pediatric patients that are undergoing tonsillectomy for sleep-disordered breathing or obstructive sleep apnea AND are to be admitted into a monitored setting will be recruited for this study. They will be randomized into two groups:1) Control group receiving continuous infusion of saline (placebo) and 2) Study group receiving continuous infusion of low-dose ketamine at 0.1 mg/kg/hr. Both patients will receive scheduled oral acetaminophen and rescue intravenous morphine as required. The infusions will be stopped at 0600 the next morning. Morphine requirements, pain scores at selected times, central nervous system side effects, and adverse cardiorespiratory events will be recorded.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
36
Post-operative continuous infusion until 0600 the next day
Post-operative continuous infusion until 0600 the next day
Health Sciences Center
Winnipeg, Manitoba, Canada
Measurement of post-operative opioid requirements after tonsillectomy in obstructive sleep apnea (OSA) patients
Influence of low-dose continuous ketamine infusion on post-operative opioid requirements after tonsillectomy in OSA patients.
Time frame: 24 hrs
Documentation of respiratory morbidity after tonsillectomy in OSA patients
Influence of low-dose ketamine infusion on respiratory morbidity after tonsillectomy in OSA patients
Time frame: 24 hrs
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