Registry of Right-to-left Shunt Detection by Contrast-enhanced Transcranial Doppler in Chinese Population

Yingqi Xing1,100 enrolled

Overview

The purpose of the study is to evaluate the prevalence and extent of right-to-left shunt (RLS) in Chinese migraineurs, and the morbidity of silent cerebral infarction in migraineurs.

This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and c-TCD). For migraineurs with large RLS further examinations (c-TTE and brain MRI) are required. Up to 10 study sites nationwide will be needed to recruit the planned participant population during a 1-year period. The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, MIDAS and HIT-6 questionnaire.

Study Type

OBSERVATIONAL

Enrollment

1,100

Conditions

Right-to-left Shunt Migraine Cerebral Infarction

Eligibility

Sex: ALLMin age: 16 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For group 1: Normal healthy individual without migraine. * For group 2: Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders. Exclusion Criteria: * Subjects with stenotic intracranial or extracranial arteries or intracranial abnormalities diagnosed with TCD.

Locations (1)

First Hospital of Jilin University

Changchun, Jilin, China

Outcomes

Primary Outcomes

contrast-enhanced transcranial Doppler

Time frame: 1 year

Secondary Outcomes

brain MRI

Time frame: 1 year

Data from ClinicalTrials.gov

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