Hypothesis: Prucalopride can mimic electrical stimulation of the abdominal vagus nerve and has an anti-inflammatory effect. Aims: In the present pilot study, the investigators want to evaluate the anti-inflammatory effect of prucalopride. The following aims are formulated: 1. to show that prucalopride has a similar inflammatory effect as abdominal vagus nerve stimulation (VNS) 2. to evaluate whether prucalopride leads to accelerated post-operative recovery
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
31
University hospitals Leuven
Leuven, Vlaams-Brabant, Belgium
Levels of pro-inflammatory cytokines in intestinal tissue, serum, peritoneal lavage and supernatant of stimulated whole blood
Time frame: From the date of surgery until the date of lab analysis (up to 6 months)
Time to first flatus
Time frame: From the date of surgery until the date of discharge from the hospital (on average 14 days)
Time to tolerance of oral food intake
Time frame: From the date of surgery until the date of discharge from the hospital (on average 14 days)
Time to tolerance of oral food intake AND first defecation
Time frame: From the date of surgery until the date of discharge from the hospital (on average 14 days)
Time to first defecation
Time frame: From the date of surgery until the date of discharge from the hospital (on average 14 days)
Gastrointestinal symptoms (nausea, pain, vomiting, bloating)
Time frame: From the date of surgery until the date of discharge from the hospital (on average 14 days)
Time to discharge from the hospital
Time frame: From the date of surgery until the date of discharge from the hospital (on average 14 days)
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