Methylprednisolone Sodium Succinate in Treating Patients With Acute Graft-versus-Host Disease of the Gastrointestinal Tract

Inclusion Criteria: * Diagnosis of acute GvHD of the GIT (any site except isolated "upper" GIT disease); other sites may be involved as well; their presence will not influence eligibility * Biopsies are strongly recommended and should be obtained, ideally, by full endoscopy including esophagogastroduodenoscopy (EGD) and flexible sigmoidoscopy or colonoscopy * However, and with an appropriate clinical presentation, it is desirable -- but not necessary -- to have pathology confirmation * If other diagnoses are excluded, it is not necessary to biopsy all potentially involved sites in the GIT to initiate therapy * It is possible that other diagnoses may be present as well, and this should not exclude eligibility so long as they are distinct (this statement is generic, but applies especially to various types of infective colitis; that said, on-going anti-infective therapy must be on-going) * Any diagnosis, donor or source of hematopoietic stem cells (HSC) is allowed, including donor leukocyte infusions (DLI) * Prior or on-going therapy: * De novo disease with no previous systemic (topical allowed) therapy for acute GvHD --except for a maximum (and ideally much less) of 72 hours of prior glucocorticoid (GC) therapy, \> 0.5 mg/kg/day of MePDSL or equivalent after the onset of acute GvHD * An exception to the above exists for patients with prior acute GvHD (of any site) who received GC therapy, experienced a complete response (CR), were tapered off GC and recurred \>= 15 days later; such are eligible after review by the principal investigator (PI) or his designee * The use of on-going acute GvHD prophylaxis will be continued * The use of any other IST is allowed if acute GvHD of the GIT develops while the patient is off all IST; IST may be started at the discretion of the attending physician after discussion with the PI of this study * Treatment with oral budesonide is to be started or continued at full dose * Please consult with the study PI regarding any questions or concerns of study eligibility * No specific organ function parameters are required; however, significant abnormalities should be discussed with the study PI * Ability to understand and the willingness to sign the Institutional Review Board (IRB)-approved informed consent document Exclusion Criteria: * Significant risk factors for IASA therapy including, but not limited to: major uncorrectable coagulopathy, bowel perforation, ongoing bacteremia, mesenteric insufficiency, etc; in these or any questionable cases, discussion with the PI is recommended * Patients may not be receiving any other drugs for the treatment of GvHD or investigational agents, except for a maximum of 72 hours of prior GC therapy, as above * Uncontrolled, severe infective processes * Patients with relapsed or persistent malignancy requiring immunosuppressive withdrawal or modulation (an example of this may be a patient who relapsed and was being treatment with DLI and then developed GvHD) * Pregnant women are excluded from this study; breastfeeding should be discontinued