A Drug Drug Interaciton Study of Imrecoxib and Warfarin in Healthy Volunteers

Inclusion Criteria: Adult males aged 18 to 40 years,with BMI 19\~24. Subjects who, in the opinion of the investigator, are healthy as determined by medical history, physical examination, and 12 Lead ECG. Willing and able to provide written informed consent. Exclusion Criteria: History of hypersensitivity to Imrecoxib and its components. History or current clinically important systemic illnesses, including but not limited to cardiovascular, pulmonary, hepatobiliary, renal, hematological, gastrointestinal, endocrinological, immunological, dermatological, neurological, or psychiatric diseases, or any conditions that may place the subject at increased risk as determined by the investigator. Any condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs. History of alcohol dependent, habitual heavy users of caffeinated beverages judged by the investigator. Have had significant blood loss (\>200mL) or have donated 1 or more units of blood or plasma within 12 weeks prior to study entry. Have a positive test at Screening for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus antibody (HCVAb). Have used any drugs or substances (including herbal supplements) known to inhibit or induce cytochrome (CYP) P450enzymesincluding CYP3A4, CYP2C8 and CYP2C9 within 4 weeks prior to the first dose and throughout the study.