A randomized, prospective, placebo-controlled study which aims to evaluate the effect of combined intraarticular and intravenous Tranexamic acid on total blood loss following unilateral knee replacement versus only intravenous tranexamic acid.
Intravenous (IV) Tranexamic acid is already well-established and well-documented regarding significant effect on reducing blood loss following knee replacement. A few studies more shown a similar effect of intraarticular (IA) injected Tranexamic acid into the knee joint at the end of surgery for knee replacement. In this study investigators therefore investigate the possible combined effect of added intraarticular tranexamic acid to conventional intravenous Tranexamic acid.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
An anti-fibrinolytic drug injected into the knee joint at the end of surgery, 3 g diluted in 30 ml saline water.
30 ml of Saline water injected into the knee capsula at the end of surgery.
An anti-fibrinolytic drug injected intravenous at the beginning of surgery for BOTH groups.
Hvidovre University Hospital
Hvidovre, Denmark
Total estimated blood loss
Time frame: 24 hours surgery
Total estimated blood loss
Time frame: 2 days after surgery
Thromboembolic complications
90 days followup for thromboembolic complications.
Time frame: 90 days postoperative
Blood transfusion
Estimate the extent of blood transfusions during admission and readmission in relation to the knee replacement
Time frame: while hospitalized expected 3 days.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.