Epidemiological and observational studies have linked vitamin D deficiency with increased asthma/allergy incidence . Vitamin D insufficiency (\<75nmol/L) has been associated with increased incidence of severe childhood asthma. Further, high 25(OH)D levels were associated with reduced risk of recent hospitalization, lower use of anti-asthmatic medication and lower airway hyper-responsiveness in childhood asthmatics. The association between vitamin D and allergy and asthma appears to be stronger in children than adults, with some even suggesting that childhood asthma may may be caused by VDD.
Asthmatic children will be recruited in winter. After baseline testing, children will be randomized to take 2,000iu vitamin D or placebo daily for 15 weeks. After the 15 weeks, testing will be repeated. Tests involve blood draws, questionnaires and breathing tests.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
53
Soft gel capsules will be identical to the vitamin D intervention but contain no vitamin D.
Soft gel capsules will contain 2,000IU vitamin D.
Paediatic Asthma Control Test (P-ACT)
Time frame: 15 weeks
Global Initiative for Asthma Score
Time frame: 15 weeks
Pulmonary function
FEV1, FVC, FEV1:FVC
Time frame: 15 weeks
Height velocity
Rate of change in height
Time frame: 15 weeks
Biochemical markers (25(OH)D, total IgE, total calcium, albumin, PTH, phosphate, hsCRP, IgA and ECP.
Time frame: 15 weeks
Mini paediatric asthma quality of life questionnaire
Time frame: 15 weeks
Asthma Diary
A 13 item diary to be filled out weekly by parents/gaurdians.
Time frame: 15 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.