14 Weeks Exercise Training on Lean Women With and Without PCOS

University of Copenhagen22 enrolled

Overview

The aim of this project is to investigate the pathophysiology of PCOS in regards to the metabolic profile including defects in insulin sensitivity in skeletal muscle and adipose tissue, and to investigate the effects of exercise training on these parameters.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Polycystic Ovary Syndrome (PCOS)

Interventions

14 weeks exercise trainingOTHER

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Women with PCOS * Hyperandrogenism and/or hyperandrogenemia * Regular menstruation * Age: 20-40 * Inactive or low physical activity level * Low to moderate fitness status Inclusion Criteria: Women without PCOS * Normal levels of plasma androgens * Polycystic ovary and/or menstrual dysfunction * Age: 20-40 * Inactive or low physical activity level * Low to moderate fitness status Exclusion Criteria: Women with and without PCOS * Pregnancy or breast feeding * Smoking * Use of birth control pills 3 mo before enrolment

Locations (1)

August Krogh Building

Copenhagen, Østerbro, Denmark

Outcomes

Primary Outcomes

Compliance to exercise training program as assessed by number of training sessions completed

Superviced training program - no. of training sessions are noted by trainer. Compliance must be higher than 80%.

Time frame: 14 weeks

No change in Body Weight

Time frame: 14 weeks

Component of metabolic syndrome

Hole body insulin sensitivity measured by HOMA index

Time frame: 14 weeks

Component of metabolic syndrome

Peripheral insulin sensitivity measured by hyperinsulinemic euglycemic clamp methods.

Time frame: 14 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.