Adjuvant Antigen Specific Immunotherapy in Patients With Advanced Renal Cell Carcinoma Using Tumor Associated Peptides

Inclusion Criteria: * Advanced renal cell carcinoma clinical stage T3 or T4, N0, M0 * N+, M0 * M1 (after complete metastasectomy) * ECOG performance status 0 or 1 * age \>18 years * at least 4 weeks since last administration of radiation- or chemotherapy * Serum levels of bilirubin \<2 mg/dl, creatinine\<2mg/dl Exclusion Criteria: * detectable distant metastasis in radiological imaging (M1) * patients unable to consent * severe cardiopulmonary disorder (NYHA \>= 3) * presence of secondary malignancy * Immunosuppressive medication (last application of glucocorticoids \> 4 weeks) * seizure * pregnancy * simultaneous participation in other active or passive immunisation treatment