Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula

Cliniques universitaires Saint-Luc- Université Catholique de Louvain6 enrolled

Overview

Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers. On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer. Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

Technetium-99m - Diethylenetriaminepentaacetic acidDRUG

99mTc-DTPA solution placed on the nebulizer reservoir

Single photon emission computed tomographyOTHER

Imaging technique to investigate lung aerosol distribution

SpirometryOTHER

FEV1, FVC assessment

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy respiratory function Exclusion Criteria: * Pulmonary disease

Locations (1)

Cliniques Universitaires Saint-Luc

Brussels, Belgium

Outcomes

Primary Outcomes

Pulmonary deposition

Single photon emission tomography combined with a CT-scan

Time frame: Immediately after nebulization by imaging technique, expected average of 15 minutes

Secondary Outcomes

Three-dimensional penetration index

Time frame: immediately after the nebulization by imaging assessment, expected average of 30 minutes

Data from ClinicalTrials.gov

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