Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine

Inje University84 enrolled

Overview

Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents. The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Fever

Interventions

GlycopyrrolateDRUG

Intravenously administered 0.005mg/Kg of glycopyrrolate in intervention group

Eligibility

Sex: ALLMin age: 12 MonthsMax age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists (ASA) Physical Status classification I * underwent surgery between 8 to 9 am * undergoing ambulatory anesthesia with ketamine Exclusion Criteria: * who required endotracheal intubation * who were administered with medications other than ketamine

Locations (1)

Ilsan Paik hospital

Goyang-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

Body temperature

measured body temperature at three times in both ears and the highest value was selected.

Time frame: every 30 minutes from base line ( up to 90min )

Secondary Outcomes

Oral secretion (VAS)

Oral secretion during the whole procedure was recorded by the researcher

Time frame: up to operative end

Data from ClinicalTrials.gov

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