A Study to Evaluate Safety and Immunogenicity of AERAS-402 Administered in HIV-negative, BCG-vaccinated, QFT (+) and (-) Adults Without Evidence of TB

Inclusion Criteria: 1. Is male or female 2. Is age 18 through 45 years on Study Day 0 3. Has completed the written informed consent process 4. Had BCG vaccination at least 5 years ago, documented through medical history or presence of scar 5. Females: Ability to avoid pregnancy from 28 days prior to administration of the study vaccine through the end of the study. 6. Has general good health, confirmed by medical history and physical examination. 7. Has Body Mass Index (BMI) between 18 and 30 (wt./ht.2) by nomogram 8. Has ability to complete follow-up period of 182 days as required by the protocol 9. Is able and willing to commit to avoiding elective surgery for the duration of the study. 10. Is able and willing to stay in contact with the study site for the duration of the study. 11. Has completed simultaneous enrollment in Aeras Vaccine Development Registry Protocol. Exclusion Criteria: 1. Acute illness on the day of randomization. 2. Fever ≥37.5°C on the day of randomization. 3. Evidence of any significant active infection on the day of randomization. 4. Used immunosuppressive medication within 45 days before entry into the study (inhaled and topical corticosteroids are permitted). 5. Received immunoglobulin or blood products within 45 days before entry into the study. 6. Received any investigational drug therapy or vaccine within 182 days before the first dose of study vaccine in this protocol. 7. Received any standard vaccine within 45 days before the first dose of study vaccine in this protocol, through the last study visit (the use of licensed drugs or vaccines medically indicated during the study is permitted). 8. Received any adenovector based vaccine previously. 9. Current chronic drug therapy including hormones such as thyroxin, insulin, etc. (Estrogen and progesterone replacement and contraceptives are permitted) 10. History or laboratory evidence of any past, present or future possible immunodeficiency state which will include, but is not limited to, any laboratory indication of HIV-1 infection. 11. History of allergic disease or reactions likely to be exacerbated by any component of the study vaccine. 12. Previous medical history that may compromise the safety of the subject in the study. 13. Evidence of a new acute illness that may compromise the safety of the subject in the study. 14. Pregnant or lactating/nursing females. 15. Evidence of chronic hepatitis including a positive test for hepatitis B core antibody, or hepatitis C antibody. 16. Inability to discontinue daily medications except contraceptives during the study. 17. History of alcohol or drug abuse within the past 2 years. 18. Tobacco or cannabis smoking three or more days per week 19. Positive urine test for illicit drugs (opiates, cocaine, amphetamines). 20. History or evidence of any systemic disease on physical examination or any acute or chronic illness that may interfere with the evaluation of the safety or immunogenicity of the vaccine, including axillary lymphadenopathy 21. History or evidence (including chest X-ray) of active or past tuberculosis 22. Abnormal hemoglobin, hematocrit, white blood cell count, absolute neutrophil count, absolute lymphocyte count, PT, PTT, GGT, ALT, AST, total bilirubin, ALP, and creatinine drawn within 36 hours of randomization. CPK must be drawn but the CPK value is not an exclusion criteria. 23. History of high risk sexual behaviors.