BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosis

Key Inclusion Criteria: * Onset of SPMS at least 1 to 2 years prior to randomization. SPMS is defined as relapsing-remitting disease followed by progression of disability independent of or not explained by relapses. * Have documented confirmed evidence of disease progression independent of clinical relapses over the 1 year prior to randomization. * Have an Expanded Disability Status Scale score of 3.0 to 6.5, inclusive. * Have a Multiple Sclerosis (MS) Severity Score of 4 or higher. Key Exclusion Criteria: * Have a diagnosis of relapsing remitting multiple sclerosis or primary progressive MS as defined by the revised McDonald criteria. * Had a recent clinical relapse (within 3 months) prior to randomization. * Uncontrolled intercurrent illness including, but not limited to: ongoing or active infection; symptomatic congestive heart failure; unstable angina pectoris; cardiac arrhythmia; serious or acute liver, kidney, or bone marrow dysfunction; uncontrolled diabetes; serious or acute psychiatric illness that would limit compliance with study requirements. Note: Other protocol-defined Inclusion/Exclusion criteria may apply