Evaluation of the Role of OCT in the Detection of HIV-associated Neurocognitive Disorder

Centre Hospitalier Universitaire Saint Pierre55 enrolled

Overview

The purpose of this study is to determine the sensitivity and specificity of the use of optical coherence tomography to detect HIV-associated neurocognitive disorder compared to MRI and usual cognitive screening tools.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

AIDS-Related Dementia Complex

Interventions

Optical Coherence TomographyOTHER

Optical Coherence Tomography provides a non invasive evaluation of the thickness of different layers of the retina

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HIV infection * Antiretroviral treatment * Undetectable plasmatic HIV viral load (viral load\<50 copies/ml) for at least 6 months * Ability to understand and give approved consent Exclusion Criteria: * Any present or past ophthalmologic illness that may impair OCT results * Previous cerebral infection with sequel * Previous cerebrovascular disease with sequel * Severe psychiatric illness * Active alcohol or drug abuse * Active chronic hepatitis C * Inability to perform french cognitive assessment * Inability to perform a MRI * Inability to perform a lumbar puncture

Locations (1)

Hopital St Pierre

Brussels, Belgium

Outcomes

Primary Outcomes

Number of patients with abnormal OCT (retinal thickness in µm) in patients with abnormal full neurocognitive evaluation

Time frame: Baseline

Secondary Outcomes

Number of patients with abnormal neuroscreen and/or modified dementia scale in patients with abnoraml full neurocognitve evaluation

Time frame: Baseline

Correlation between retinal thickness (in µm) and cerebral atrophy in % of brain parenchymal fraction ( measured by cerebral MRI)

Time frame: Baseline

Data from ClinicalTrials.gov

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