Phase I Study of INO-1800 With or Without INO-9112 + EP in Chronic Hepatitis B Subjects

INCLUSION CRITERIA: * Chronic Hepatitis B virus infection * Negative for Hepatitis A IgM, C, D and HIV * Liver biopsy, Fibroscan® or equivalent elastography-based test obtained within the past 6 months demonstrating liver disease without evidence of bridging fibrosis or cirrhosis supported by platelet count greater than the central laboratory LLN at screening * Positive for Hepatitis B surface antigen (≥250 IU/mL at screening) * Nucleos(t)ide treatment for at least 1 year with ongoing nucleos(t)ide analogue treatment at randomization * HBV DNA \<90 IU/mL for ≥6 months prior to randomization * Screening laboratory values within normal range * ALT ≤1.5x upper limit of normal (ULN) from 2 measurements separated by at least 14 days during the 6 months prior to randomization and ALT at screening ≤1.5x ULN * AST, TBili, DBili, GGT, Alk Phos and albumin within normal range or judged to be not clinically significant by PI and medical monitor at screening * For men and women who are not postmenopausal \[i.e. ≥ 12 months of non-therapy-induced amenorrhea, confirmed by follicle stimulating hormone (FSH), if not on hormone replacement\] or surgically sterile (vasectomy in males or absence of ovaries and/or uterus in females) agreement to remain abstinent or use 1 highly effective or combined contraceptive methods that result in a failure rate of \< 1% per year during the treatment period and at least through week 12 after last dose EXCLUSION CRITERIA: * Pregnant or breastfeeding females * Positive serum pregnancy test at screening or positive urine pregnancy test at randomization * Use of topical corticosteroids at or near the intended administration site * Autoimmune disorders, transplant recipients, other immunosuppression including any concurrent condition requiring the use of immunosuppressive/immunomodulating agents (eye drop-containing and infrequent inhaled corticosteroids are permissible) * Need for systemic antiviral treatment (other than for chronic hepatitis B infection) * Documented history or other evidence of decompensated liver disease (e.g., ascites, bleeding from esophageal varices, Child-Pugh clinical classification B or C) * History of liver cirrhosis demonstrated by biopsy, Fibroscan® or equivalent elastography-based test * History of other evidence of a medical condition associated with chronic liver disease \[e.g., hemochromatosis, autoimmune hepatitis, alcoholic liver disease, non-alcoholic steatohepatitis (NASH), toxin exposure, thalassemia, etc.\] * Documented history or other evidence of metabolic liver disease within 1yr of randomization * Abnormal renal function including serum creatinine \>ULN or calculated creatinine clearance \<70 mL/min (using the Cockcroft Gault formula) * History of or suspicion of HCC * Screening alpha fetoprotein ≥13 ng/mL * Prior history or current malignancy other than adequately treated BCC, unless history of BCC is near intended administration site * History of significant medical conditions \[e.g., cardiac (including ventricular or supraventricular arrhythmias), renal disease, pulmonary, gastrointestinal, neurological\] * Significant acute infection (e.g., influenza, local infection) or any other clinically significant illness within 2 weeks of randomization * Administration of any blood product within 3 mon of randomization * History of seizures (unless seizure free for 5yrs)