Poor ovarian response indicates inadequate ovarian response to ovarian stimulation. In the current study the investigators will attempt to compare antagonist and short protocols regarding oocyte as well as embryo quantity and quality. Frozen embryo transfer will be performed in order to abolish iatrogenic effect of stimulation drugs on implantation. Still implantation and pregnancy rates are considered secondary outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
400
controlled ovarian hyperstimulation with various protocols, follow up till stimulated follicles measure from 18-20 mm, then ovum pickup followed by embryo transfer is done.
IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini)
Cairo, Egypt
Kamal Shaeer center of infertility
Giza, Egypt
Nile IVF center
Giza, Egypt
Number of Metaphase II (MII) oocytes
Number of MII oocytes collected from each patient on the day of ovum pickup (OPU)
Time frame: 9-14 days from stimulation
Number of good embryos
the number of good quality embryos obtained from each patient
Time frame: 3-5 days after ovum pickup
chemical pregnancy rate
positive serum Beta HCG 14 days after embryo transfer
Time frame: 14 days after embryo transfer
clinical pregnancy rate
the detection of intrauterine gestational sac with positive pulsations
Time frame: 5 weeks after embryo transfer
Implantation rate
the ratio between the number of embryos transferred and the number of sacs
Time frame: 5 weeks after embryo transfer
Early miscarriage rate
Pregnancy loss in the first 12 weeks gestation
Time frame: 3 months
Ongoing pregnancy rate
Pregnancy ongoing beyond 12 weeks gestation
Time frame: 3 months
Live birth rate
Pregnancy ending with a live birth
Time frame: 9 months
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