Interest of the F18-choline as a Second Line of the Tracer for Detection of Parathyroid Adenomas

Centre Francois Baclesse28 enrolled

Overview

The rationale for the proposed pilot study is to investigate the ability of PET-CT with F18-choline to detect and locate the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory MIBI (Tc-99m sestamibi) and cervical ultrasound, in order to avoid unnecessary bilateral cervical exploration.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Hyperparathyroidism

Interventions

F18-choline PET examinationRADIATION

F18-choline PET examination will be performed before surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient aged 18 years or more; * Patient with a primary hyperparathyroidism and witj a negative or non-contriburatory MIBI parathyroid scintigraphy and neck ultrasonography, for which surgical resection is planned; * Confirmation of the diagnosis of primary hyperparathyroidism on laboratory tests * Affiliate to a social security system; * Patient written informed consent. Exclusion Criteria: * Patient deprived of liberty, under guardianship; * Any medical or psychological condition witch could compromise the capacity of the patient to participate in the study; * Pregnant or breastfeeding

Locations (2)

CHU

Caen, France

Centre François Baclesse

Caen, France

Outcomes

Primary Outcomes

Sensitivity (ability to identify and visualize the parathyroid adenoma)

Sensitivity of PET-CT with F18-choline (FCH) to identify and visualize the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory parathyroid scintigraphy MIBI and cervical ultrasound

Time frame: Up to 2 months

Data from ClinicalTrials.gov

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