The study primarily aims to compare the effects of two doses of Corever with placebo in patients with hypertension.
The study aims to compare the effects of two doses of Corever with placebo in patients with essential hypertension. Eligible subjects who belong to one of the following subtypes are planned to be enrolled: (1) patients with essential hypertension without drug control, or (2) uncontrolled hypertension despite treatment with up to 2 antihypertensive agents. Of note, the second category will receive randomized study treatments in addition to continuing their previous medication throughout the trial. The study also wants to investigate the safety profile of Corever during treatment period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
134
Corever
Hualien Tzu Chi Hospital
Hualien City, Taiwan
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Chung Shan Medical University Hospital
Taichung, Taiwan
Seated Office SBP reduction (SBP each visit-SBP visit 2)
To compare the change in office SBP measurements by cuff assessments after 8 weeks of treatment
Time frame: 8 weeks
Seated Office DBP reduction (DBP each visit-DBP visit 2)
1. To compare the change in office DBP measurements by cuff assessments after 8 weeks of treatment 2. To compare the percentage of subjects who achieve BP goal as measured by cuff assessments (140/90 mmHg) after 8 weeks of treatment
Time frame: 8 weeks
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Taichung Veterans General Hospital
Taichung, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan