Trial of the Treatment of Chronic Laryngitis With Amitryptiline

Inclusion Criteria: * Age 18 or older and able to consent for themselves. * Structural pathology such as tumor previously ruled out using flexible laryngoscopy. * Able to speak and read the English language. * Failed a trial of a proton pump inhibitor for the treatment of gastopharyngeal reflux. * Women under 55 years of age who may become pregnant must have a negative pregnancy test and agree to barrier or hormonal methods of contraception during the study. Exclusion Criteria: * Environmental allergies. * Smoking within past 5 years. * Using ginko bilboa (or unwilling to cease using it). * Current upper respiratory infections. * Use of narcotics (e.g. oxycodone, methadone). * Any prior history of amitryptiline use. * Use of monoamine oxidase inhibitors (MAOIs) within the past 4 weeks (selegiline, phenelzine, tranylcypromine, isocarboxazid, rasagiline, phenelzine sulfate, selegiline hydrochloride, rasagiline mesylate, tranylcypromine sulfate). * History of urinary retention. * Any history of major depressive disorder. * Any prior history of allergy to a tricyclic antidepressant. * Current diagnosis of gastroesophageal reflux (GERD). * For women 18-55 years of age without history of menopause: currently nursing or pregnant, plans to become pregnant, or unwillingness to utilize contraception (barrier or hormonal methods).