The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity

Norwegian University of Science and Technology16 enrolled

Overview

Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow. Explanations have therefore in addition been linked to mitochondrial dysfunction of skeletal muscles. This study will elucidate whether there is a relation between clinical variables of the different levels of arterial insufficiency in peripheral arterial disease and mitochondrial respiratory capacity.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intermittent Claudication

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Asymptotic peripheral arterial disease (Ankle-brachial index \< 0.9), intermittent claudication (Ankle-brachial index 0.4 - 0.9), or critical limb ischemia (Ankle-brachial index \< 0.4) Exclusion Criteria: * Diagnosed with intermittent claudication secondary to vascular insufficiency * Warfarin or heparin usage * Underwent a vascular intervention in the last 6 months * Active cancer, renal- or liver disease

Locations (1)

Department of Circulation and Medical Imaging

Trondheim, Norway

Outcomes

Primary Outcomes

mitochondrial respiratory capacity

measured in oxygen glux in pmol.s-1.mg-1, using mitochondrial respirometry on an Oxygraph-2k (Oroboros Instruments, Austria).

Time frame: 1 hour

Data from ClinicalTrials.gov

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