The investigators propose to study 30 adolescents with bipolar disorder, not otherwise specified (BD NOS) and a family history of Bipolar I Disorder (BD) at baseline with rs-fMRI (functional magnetic resonance imaging) and functional connectivity (FC) analyses and compare data with previously acquired rs-fMRI and FC data from 20 age- and gender-matched healthy controls (HC). Subjects will then undergo a 12-week Mindfulness based stress reduction- teen (MBSR-T) intervention and be reassessed and rescanned. The intervention and scanning will take place in groups of 6-8 subjects/group/year over the 4 years. This proposal will be a natural progression of past research, while extending the investigators' expertise to include advanced FC analyses and mindfulness based interventions in youth with mood dysregulation. The investigators will also integrate trainees into the imaging and therapy components of this study, furthering our mission of mentoring the next generation of innovative researchers who will push the field forward.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
14
A 12-Week weekly group intervention to train adolescents in mindfulness practice
Stanford University School of Medicine
Stanford, California, United States
Dorsal Medial Network functional connectivity
(1) Use ICA to compare DMN in subjects with BD NOS to healthy controls (HC)
Time frame: 12 weeks
Functional connectivity of sgACC with thalamus, VMPFC, and amygdala
(2) Investigate level of FC of the sgACC with thalamus, VMPFC, amygdala, and FC of pCing with amygdala/hippocampus, comparing subjects to HC.
Time frame: 12 weeks
Degree of Mindfulness
Will use measures of self report to determine amount and quality of mindfulness practice and degree of daily mindfulness achieved
Time frame: 12 weeks
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